Cholesterol Support Product Buyer’s Guide (updated May 2024)

Product Comparison

Approved Science Cholestrin
Dr. Sinatra Advanced Cholesterol Support
Nature Made CholestOff Plus®
OptiCel Heart Health
Contains Baca-Syl™ Berry Complex, a patented full-spectrum antioxidant blend for a wide range of cholesterol & heart health benefits.
Contains the bioactive compound Berberine for blood sugar, cholesterol, triglyceride, and insulin sensitivity benefits.
Incorporates a high dose of Lecithin (preferably sunflower-derived) for optimal balancing of total cholesterol.
Contains Policosanol to decrease cholesterol production in the liver, reduce clot formation, and increase the breakdown of LDL.
Contains BioPerine®
No additives, preservatives, or artificial ingredients
100% Money Back Guarantee


Rating: Excellent


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Editor’s Choice

Approved Science Cholestrin Review

If you want to optimally balance your total blood cholesterol levels, Approved Science Cholestrin is the product that will get the job done. Of all the cholesterol support supplements currently available on the market, this is the one that deserves a closer look and very likely, the one that will change your life!

It contains the highest quality natural ingredients in the correct dose and potency. Cholestrin contains sunflower-derived Lecithin and Policosanol, in powerful doses that are supported by clinical studies.  It also contains the patented Baca-Syl™ Berry Complex with Aronia berries, Acai berries, Blueberries and Bilberries that are rich in antioxidants and plant stanols and sterols to reduce cholesterol absorption and promote healthy blood vessels. Additionally, it contains Berberine which can lower blood sugar, improve cholesterol and triglyceride levels, and increase insulin sensitivity for optimal cardiovascular health, as well the patented BioPerine® which increases the bioavailability of ingredient absorption for faster, more effective results. 

Quality: Cholestrin contains high grade, 100% natural, clinically verified ingredients that are GMP certified.

Reputation: Approved Science’s reputation is excellent. This manufacturer has several third party monitoring services, including buySAFE, Norton, and Trustee, as well as an A+ rating from the quality monitoring company QualityTrusted.

Money-Back Guarantee: Every item sold is supported by a 60-day 100% Money-Back Guarantee. Such guarantees from manufacturers show a strong confidence in their products’ ability to deliver results – great news for consumers.

Additionally, they are well known in the industry and an established company that provides great customer support service, secure and easy checkout, as well as prompt, efficient delivery.

Their commitment to the health industry and their consumers is excellent, providing further qualification of efficacy by producing their products in an FDA registered laboratory.

If you are looking for a product that ticks all boxes, and is from an established reputable company with an excellent money-back guarantee, this is the supplement to try in order to balance total blood cholesterol levels and receive a wide range of heart health benefits.

It would be good to note that, due to high demand, Cholestrin is often sold out. To avoid having to back order, don’t hesitate to make that purchase when you see it in stock.

See the full review


Rating: Good



Dr. Sinatra Advanced Cholesterol Solutions

Dr. Sinatra Advanced Cholesterol Solutions is a supplement that uses citrus fruit extract in order to provide a wide range of heart-health benefits and cholesterol support. This citrus fruit extract is also a patented ingredient, which means that it has components that have been proven useful in studies and can be trusted. 

This product also provides an excellent money-back guarantee, which allows us to understand that the company puts their money where their mouth is, and can back up any claims of their product working well with a money back guarantee. 

This product had a fair amount of reviews on multiple websites including the company’s main site. There were some good reviews, which mostly dealt with their good customer service and speedy delivery. On the other hand, many of the negative reviews had to do with the fact that the product did not deliver the results that were promised, and did not lower LDL levels or help with the consumer’s cholesterol ratios.  

The reviews that we saw did not shock us, as we had already taken a look at the ingredients in this formula and were surprised to see that there were a lot of necessary cholesterol-support components that were left out. There are also no ingredients for better nutrient absorption, which ends up making a supplement such as this one lose some of it’s nutritional value. One of the positive sides of this product is that the main site shares information about the science and studies behind the ingredients, which we very much appreciate. Read on to discover why we chose this supplement for our #2 position.

Click here to read the full review


Rating: OK



Nature Made Cholestoff Plus

Nature Made Cholestoff Plus is a single active-ingredient based supplement that is supposed to be fairly useful in a general sense. It contains a high dose of plant sterols/stanols extracted from pine trees, and much lower doses of other inactive ingredients that would be better applied in higher potencies. 

This product contains no artificial flavors, synthetic dyes, or preservatives, and is gluten free. However, this product does not contain any money back guarantee, and has no information about third-party testing on its website. Additionally, you cannot buy Cholestoff directly from the manufacturer’s website. Instead, the product is only sold on Amazon, and therefore the return policy is the standard Amazon policy and not backed by the actual manufacturer. 

This product seems like a very standard, albeit cheap, option for those suffering from cholesterol issues. It might be helpful when attempting to alleviate very general cholesterol problems, but the ingredients don’t reflect a well thought-out and designed product. We also took issue after reading one of the reviews on Amazon – read our full review to find out more.

Click here to read the full review

What You’ll Discover:

Which Cholesterol Support Product is the BEST BUY and comes with a great GUARANTEE!
Which formula and ingredients are the most EFFECTIVE and work the fastest?
How NOT to get ripped off! BE AWARE of poor quality and cheap products.

Top 6 Items to Consider:

  1. Ingredients
  2. Cost Per Serving
  3. Product’s Testing Results
  4. Company’s Reputation
  5. Consumer Reviews
  6. Return Policy & Satisfaction Guarantee

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